Publications

Warren S^#, El Farran B^#, Kang S, Choudhuri A, Xiong S, Brendel P. V, and Baizabal JM*. (2024). A PRDM16-CTBP1/2 Complex Interacts with HDAC1/2 to Regulate Transcriptional Programs of Neurogenesis and Guide Cortical Neuron Migration. BioRxiv, doi: https://doi.org/10.1101/2024.11.17.624022.

Chang YC, Yang S, Cho M, Nho K, Baizabal JM, Lu HC. (2024). Transcriptional Regulation of human NMNAT2: Insights from 3D Genome Sequencing and Bioinformatics. BioRxiv, doi: https://doi.org/10.1101/2024.11.07.622375.

Xie Q, Du Y, Ghosh S, Rajendran S, Cohen-Gadol AA, Baizabal JM, Nephew KP, Han L, and Shen J. (2024). Multi-omic Analysis Identifies Glioblastoma Dependency on H3K9me3 Methyltransferase Activity.BioRxiv, doi: https://doi.org/10.1101/2024.04.18.590173.

Warren S, Xiong S, Robles-Magallanes D, Baizabal JM*. (2024). A Vector System Encoding Histone H3 Mutants Facilitates Manipulations of the Neuronal Epigenome. Scientific Reports, 14, 24415.

Suresh V^#, Bhattacharya B^#, Yair Tshuva R^#, Danan Gotthold M, Olender T, Bose M, Pradhan S, Ben Zeev B, Scott Smith R, Tole S, Galande S, Harwell C, Baizabal J-M*, Reiner O*. (2024). PRDM16 co-operates with LHX2 to shape the human brain. Oxford Open Neuroscience, 3, 1–16.

* Equal contribution 

García MT, Baizabal JM, Tran D, Peixoto R, Wang W, Xie Y, Adam MA, English LA, Reid CM, Brito S, Booker MA, Tolstorukov MY, Harwell CC. (2020). Transcriptional regulation of MGE progenitor proliferation by PRDM16 controls cortical GABAergic interneuron production. Development, Oct 15; doi: 10.1242/dev.187526.

Baizabal JM*, Mistry M, García MT, Gómez N, Olukoya O, Tran D, Johnson MB, Walsh CA, Harwell CC*. (2018). The Epigenetic State of PRDM16-Regulated Enhancers in Radial Glia Controls Cortical Neuron Position. Neuron, Jun 6; 98(5):945-962. Extended PDF.

*Co-corresponding authors

In the news:

• Recommended by Faculty of 1000
• Highlighted by the Harvard Brain Science Initiative
• Highlighted by the Harvard Medical School news
• Preview in Neuron. Influence without Presence: PRDM16 Casts Destiny

Trujillo-Paredes N, Valencia C, Guerrero-Flores G, Arzate D, Baizabal JM, Guerra Crespo M, Fuentes-Hernández A, Zea-Armenta I, Covarrubias L. (2016). Regulation of differentiation flux by Notch signaling influences the number of dopaminergic neurons in the adult brain. Biology Open, 5:336-347.

Peterson KA, Nishi Y, Ma W, Vedenko A, Shokri L, Zhang X, McFarlane M, Baizabal JM, Junker JP, van Oudenaarden A, Mikkelsen T, Bernstein BE, Bailey TL, Bulyk ML, Wong WH, McMahon AP. (2012). Neural-specific Sox2 input and differential Gli-binding affinity provide context and positional information in Shh-directed neural patterning. Genes and Development, 26(24):2802-16.

Sanchez-Sanchez R, Morales-Lazaro S, Baizabal JM, Sunkara M, Morris AJ and Escalante-Alcalde D. (2012). Lack of Lipid Phosphate Phosphatase-3 in Embryonic Stem Cells Compromises Neuronal Differentiation and Neurite Outgrowth. Developmental Dynamics, 241(5):953-64.

Baizabal JM, Cano A, Valencia C, Santa-Olalla J, Young K, Rietze R, Bartlett PF and Covarrubias L. (2012). Glial Commitment of Mesencephalic Precursor Cells Expanded as Neurospheres Precludes Their Engagement in Niche-Dependent Dopaminergic Neurogenesis. Stem Cells and Development, 21(7):1047-58.

Baizabal JM, Valencia C, Guerrero G and Covarrubias L. (2011). Telencephalic Neural Precursor Cells Show Transient Competence to Interpret the Dopaminergic Niche of the Embryonic Midbrain. Developmental Biology, 349(2):192-203.

Baizabal JM and Covarrubias L. (2009). The Embryonic Midbrain Directs Neuronal Specification of Embryonic Stem Cells at Early Stages of Differentiation. Developmental Biology, 325(1):49-59.

Cárdenas MC, Santa-Olalla J, Baizabal JM, Salgado LM and Covarrubias L. (2003). Growth Factor Deprivation Induces an Alternative Non-apoptotic Death Mechanism that is Inhibited by Bcl-2 in Cells Derived from Neural Stem Cells. The Journal of Hematotherapy and Stem Cell Research, 12:735-48.

Baizabal JM, Furlan MM, Santa-Olalla J and Covarrubias L. (2003). Neural Stem Cells in Development and Regenerative Medicine. Archives of Medical Research, 34:572-88.

Santa-Olalla J, Baizabal JM, Fregoso M, Cárdenas MC and Covarrubias L. (2003). The In vivo Positional Identity Gene Expression Code is not Preserved in Neural Stem Cells Grown in Culture. European Journal of Neuroscience,18:1073-84.